British Air Force Typhoon jets have operated alongside French aircraft in a combined operation on an underground arms cache in Syria employed by the IS group, per a report from the UK's MoD.
The site, identified by intelligence, was assessed as containing munitions and bombs, the announcement noted, and was located in mountainous terrain just north of the historic site of Palmyra in the heart of Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to target a several approach shafts providing entry to the facility... early reports are that the strike was effective," the MoD said.
There was no evidence of any civilian casualties in the operation late on Saturday and every plane involved returned safely, the MoD added.
The British jets were assisted by a Voyager tanker plane.
The Islamic State group - referred to as ISIS - imposed militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates the UK's leading role, and commitment to operate in unison with our partners, to eradicate any re-emergence of IS and their violent and radical beliefs in the region," Britain's Defence Chief the Defence Secretary stated.
RAF aircraft have conducted patrols over Syrian airspace to "deter any efforts to regroup" of IS after its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to every member of British forces who took part in this mission for their skill and their courage," he added. "Including them were a great many British troops deployed over the holidays. This mission, to eliminate militants who endanger our security, demonstrates how British military are prepared to act, all year round, ensuring Britain's security within its borders and strong abroad."
During December, the United States armed forces executed what it described as a "massive strike" on IS targets in the country, after an attack claimed the lives of two US servicemembers and a civilian linguist in the Palmyra area.
The UN estimates Daesh still maintains roughly 5-7 thousand combatants in both countries.